The Mississippi River is notorious for holding catfish pushing triple digit weights, flesh-eating alligator gar over two-hundred pounds, water moccasins, alligators, and even bull sharks. Top to bottom, it's a river teeming with top-tier predators. But there's something else in the water, something far more ancient and evil, something that has been dormant for thousands of years. Now, as Jed Wilkes, a New Orleans casino baron, prepares for the grand opening of his greatest endeavor yet-a floating casino on the Mississippi-these primordial river monsters are just waking up. Faced with losing his lifetime dream, Jed must team up with his ex-wife's new husband, Louisiana's greatest big-game hunter, to track down and kill off the river monsters before opening night.