Findings and reviews by foremost experts offer a comprehensive survey regarding the present state of our understanding of the development of Alzheimer disease in people with Down Syndrome and the relationship between these disorders. Coverage includes many processes involved in the pathogenesis of Alzheimer disease, the latest molecular and cellular techniques for defining these processes, the usefulness of animal model systems for studying normal and abnormal development and function of the central nervous system, the relationship between chromosome 21 and Alzheimer disease and much more.