Chloe is a pampered Beverly Hills chihuahua who, while on vacation in Mexico with her owner's niece, Rachel, gets lost. She must rely on her new friends to help her get back home before she is caught by a dognapper who wants to ransom her. In the meantime, Papi, a male chihuahua who is in love with Chloe goes in pursuit of her. Papi's owner is a handsome young gardener for Rachel's aunt Viv. He slowly develops a romantic interest in Rachel. Chloe befriends Delgado, a lonely German Shepherd, who travels with her and protects her from Diablo, the evil Doberman, who wants to return her and her diamond collar to the dognapper.