Together, Catwoman, Harley Quinn and Poison Ivy are three of Gotham City's most powerful quasi-reformed criminals, and together they spark scandal wherever they go.But when Harley stages a riot in Arkham Asylum for The Joker, it could be the beginning of the end of the Gotham City Sirens. As the situation inside Gotham quickly spins out of control, and Harley becomes more and more mired in her obsession with the Clown Prince of Crime, Poison Ivy and Catwoman struggle over how to handle their estranged teammate. The Gotham City Sirens are ready to make their final stand, but will they be fighting each other?