Turned down for this years Nobel Prize, forty-two year old genetics pioneer Grace Farrington finds out the new Head of Research of Oyster River is the man who stole her work! When Dr. Marshall is murdered on ORR's house boat, Grace finds herself chief suspect. She is further implicated when following an 1800's witch's Curse of Three, two more people die in Oyster River Harbor. While finding herself romantically involved with a billionaire patron and a red necked colleague, Grace must use her scientific reasoning and her eclectic group of friends (cops, seance buddies, fishermen and some other slightly eccentric New Englanders) to solve the murders before she's arrested.