Comprehensively presents the foundations and leading application research in medical informatics/biomedicine. The concepts and techniques are illustrated with detailed case studies. Authors are widely recognized professors and researchers in Schools of Medicine and Information Systems from the University of Arizona, University of Washington, Columbia University, and Oregon Health & Science University. Related Springer title, Shortliffe: Medical Informatics, has sold over 8000 copies The title will be positioned at the upper division and graduate level Medical Informatics course and a reference work for practitioners in the field.