This text/reference in toxicology is now in its third edition, revised and updated to reflect major developments in the field. The expanded coverage of toxicology principles includes new chapters on physiologically-based pharmacokinetics, pharmaceuticals and biotechnology products, metals, and radiation. The chapters on the regulatory process, pharmacokinetics, food- borne toxicants, solvents and vapours, pesticides, and genetic toxicology have been updated; and a new chapter on the history and practice of toxicology has been included. New in the methods section are chapters on environmental toxicity and behavioural toxicity.