Centers around the lives and loves of 5 young surgical interns at Seattle Grace Hospital. Placed in the most competitive and grueling internship a hospital has, these young interns learn how to become surgeons from some of the best in the business. Derek's previously unknown wife, Addison shows up and tries to win back her busband. Confronted with the two women he loves, Derek is forced to choose between them, a choice that will have wide reaching consequences. Christina and Burke's relationship continues to develop, Izzy and Alex continue to have chemistry, and Meredith still has unfinished feelings for Derek.