This book evaluates the risk to human health of ethylene glycol. Ethylene glycol is a colorless, odorless, sweet-tasting, relatively non-volatile liquid. It is used in the manufacture of poly-ethylene terephthalate, in natural gas processing, and as an antifreeze agent. Available data from acute poisoning cases (humans) and repeated-dose toxicity studies (experimental ani-mals), indicate that the kidney is a critical organ for the toxicity of ethylene glycol in both humans and experimental animals.