August 1914. While Europe enters a brutal conflict unlike any waged before, the Duncan household in Baltimore, Maryland, is the setting for a different struggle. Ruth and Elise Duncan long to escape the roles that society, and their controlling father, demand they play. Together, the sisters volunteer for the war effort, Ruth as a nurse, Elise as a driver. Stationed at a makeshift hospital in Ypres, Belgium, Ruth soon confronts war's harshest lesson: not everyone can be saved. Rising above the appalling conditions, she seizes an opportunity to realize her dream to practice medicine as a doctor. Elise, an accomplished mechanic, finds purpose and an unexpected kinship within the all-female Ambulance Corps. Through bombings, heartache, and loss, Ruth and Elise cherish an independence rarely granted to women, unaware that their greatest challenges are still to come.