After emerging from a coma, Faye Wills opens her eyes to complete darkness and the feeling of being trapped. She awakens in the worst place imaginable, one of thousands of bodies in a makeshift mass grave that was once a football stadium. Left for dead, there are no signs of life and the only sound she hears is the buzzing of flies that follow the stench of death. Once out of the stadium she steps into a desolate, barren world, void of all life and people. Faye learns that while in a comatose state, the world was besieged by some sort of epidemic. Without a soul around, there are a lot of missing pieces. Where did everyone go? In her weakened state, she must pull it together and move forward to find answers and survivors. However, she soon realizes that she may never find anyone and must face the possibility that she may be The Last Woman on earth.