40-something Hannah, 50-something Mitsy, and 60-something Pandora, indulge in a creative assortment of addictions that obscure the mysterious connection to a common past that haunts them all. The link to their recovery is Sydney, the child among them, and the stake they all share in her perilous condition and unlikely cure. As Sydney submits to weekly treatments for an illness she refuses to grace with a name, she plays 'The Anesthesia Game', a game that ultimately leads her to the origin of her disease and a way out of the struggle that binds them all.